Dr. Morris Scantlebury is an Associate Professor in the Departments of Pediatrics and Clinical Neurosciences at the University of Calgary. He also is a pediatric neurologist at the Alberta Children’s Hospital in Calgary and is a member of the Alberta Children’s Hospital Research Institute for child and maternal health with a lab in the developmental epilepsy research program. Dr. Scantlebury has a broad background in pediatric epilepsy research, specifically in the development and characterization of animal models of pediatric epilepsy syndromes. His current research focus is to identify new treatments for the catastrophic infantile spasms syndrome. Dr. Scantlebury also investigates the mechanisms of febrile seizures, which is the most common form of seizures to affect children.
Current Lab Members
Development of novel non-pharmacologic treatments for Infantile Spasms
Role of heat sensitive channels in febrile seizures
Breathing and Epilepsy
Role of microbiota in epilepsy
1. Barrett K, Choudhary A, Charkhand B, Scantlebury MH. Animal Models of Epileptic Spasms and the Development of Novel Treatment Options JCNP 2019 (in press)
2. Barrett KT, Hasan SU, Scantlebury MH, Wilson RJA. Impaired neonatal cardiorespiratory responses to hypoxia in mice lacking PAC1 or VPAC2 receptors. Am J Physiol Regul Integr Comp Physiol. 2019 Feb 13. doi: 10.1152/ajpregu.00250.2018. PMID: 30758978
3. Barrett KT, Roy A, Rivard KB, Wilson RJA, Scantlebury MH. Vagal TRPV1 activation exacerbates thermal hyperpnea and increases susceptibility to experimental febrile seizures in immature rats. Neurobiol Dis. 2018 Nov;119:172-189. doi: 10.1016/j.nbd.2018.08.004. Epub 2018 Aug 16. PMID: 30121230
4. Sarnat HB, Scantlebury MH. Novel Inflammatory Neuropathology in Immature Brain: (1) Fetal Tuberous Sclerosis, (2) Febrile Seizures, (3) α-B-crystallin, and (4) Role of Astrocytes. Semin Pediatr Neurol. 2017 Aug;24(3):152-160. PMID:29103422
5. Scantlebury MH, Chun KC, Ma SC, Rho JM, Kim DY. “Adrenocorticotropic Hormone Protects Learning and Memory Function in Epileptic Kcna1-null mice.” Neuroscience Letters; 2017 Apr 3; 645:14-18. PMID: 28249786.
6. Barrett KT, Wilson RJ, Scantlebury MH. “TRPV1 deletion exacerbates hyperthermic seizures in an age-dependent manner in mice.” Epilepsy Res; 2016; 128:27-34. PMID: 27810513.
7. Myers K, Bello-Espinosa LE, Scantlebury MH. “Infraslow electroencephalography changes in infantile spasms.” JCNP; 2014 Dec; 31(6):600-5. PMID: 25462149.
8. Scantlebury MH, Heida JG. “Febrile seizures and temporal lobe epileptogenesis.” Epilepsy. Res.2010; 89(1): 27-33. PMID: 20005077.
9. Scantlebury MH, Galanopoulou AS, Chudomelova L, Raffo E, Betancourth D, Moshe SL. A model of symptomatic infantile spasms syndrome. Neurobiol Dis. 2010; 37(3):604-12. PMID: 19945533.
10. Gibbs SA, Scantlebury MH, Awad P, Lema P, Essouma JB, Parent M, Descarries L, Carmant L. Hippocampal atrophy and abnormal brain development following a prolonged hyperthermic seizure in the immature rat with a focal neocortical lesion. Neurobiol Dis. 2008; 32:176-182. PMID: 18678257.
11. Scantlebury MH, Gibbs SA, Foadjo B, Lema P, Psarropoulou C, Carmant L. Febrile seizures in the predisposed brain: a new model of temporal lobe epilepsy. Ann Neurol. 2005; 58:41-49. PMID: 15940665.
12. Scantlebury MH, Ouellet P-L, Psarropoulou C, Carmant L. Freeze lesion-induced focal cortical dysplasia predisposes to atypical hyperthermic seizures in the immature rat. Epilepsia.2004; 45(6):592-60. PMID: 15144423.
Dr. Wendie Marks, PhD. (Post Doctoral Fellow)
Dr. Chunlong Mu, PhD. (Post Doctoral Fellow)
Ms. Sydney Harris, MSc. (Masters Student)